McNeese State will open its 2015 football season against LSU, the schools announced on Wednesday.
It will be McNeese's second game against LSU.
The Cowboys and Tigers will play Sept. 5, 2015, in Tiger Stadium.
McNeese and LSU first played Oct. 16, 2010, when the Tigers won 32-10.
That contest was the first-ever game the Tigers had played an in-state Football Championship Subdivision team. Since then, LSU has played only one other FCS school from the state: Northwestern State in 2011.
"We are excited to open the 2015 season at LSU," said McNeese head coach Matt Viator. "To play one of the best programs in the country, in one of the premier venues, is a great opportunity for our program."
The game in 2010 drew 92,576 in attendance, the largest crowd ever for McNeese.
"That game was a first-class experience both on and off the field for the entire community," said Viator.
McNeese opens the 2014 season at Nebraska and opened last two seasons with wins at Middle Tennessee and South Florida – both FBS programs.
Since 2000, the Cowboys have played 16 games against the higher division schools, winning four of those. McNeese is 3-7 against the FBS under Viator.